Marie Fleming, who lost a landmark Supreme Court right-to-die challenge earlier this year, has passed away.
The 59-year-old had multiple sclerosis. She had been diagnosed with the disease in 1989.
As the latter stages of the illness took hold she was confined to a wheelchair, required 24-hour care and found it increasingly difficult to talk.
She took a highly-publicised Supreme Court right-to-die case in April.
Physically unable to end her own life, she wanted her partner, Tom Curran, to help her without fear of prosecution.
She argued that the ban on assisted suicide breached her constitutional rights and discriminated against her as a disabled person.
Giving evidence herself, she told the seven judges that she had constant, unbearable pain in every joint of her body.
She said she had suffered with MS for 24 years and knew her pain limit had reached the end.
The Supreme Court ruled against her, finding that there was no constitutional right to die or to be assisted to do so.
However, the court said there was nothing to prevent the introduction of legislation to deal with cases such as that of Ms Fleming.
The former university lecturer died overnight.